Assistant Professor
Department of Chemistry and Biochemistry; Botulinum Research Center; Biomedical Engineering and Biotechnology
Education
Ph. D. National Chemical Laboratory (Division of Organic Chemistry), The University of Pune, Pune, India.
M. Ed. Karnataka State Open University, Mysore, India.
M. Sc. Regional Institute of Education, National Council of Educational Research and Training (NCERT), Mysore, India.
Courses (MyCourses)
CHM 161 - Introduction to Applied Chemistry I
CHM 251 - Organic Chemistry I
CHM 252 - Organic Chemistry II
CHM 263 - Bio-organic Chemistry Laboratory I
CHM 264 - Bio-organic Chemistry Laboratory II
CHM 265 - Organic Chemistry Laboratory I
CHM 266 - Organic Chemistry Laboratory II
CHM 491 - Introduction to Research I
CHM 492 - Introduction to Research II
CHM 495 - Independent Study
CHM 550 - Advanced Stereoselective Synthesis
CHM550 - Chemical Biology
CHM 600 - Thesis Research
CHM 650 - Graduate Seminar
Research Interests:
Research interests of my group lie in the general area of organic synthesis with a focus on the development of new strategies for the preparation of complex molecules possessing interesting structural, biological, and physical properties. Our research interests are interdisciplinary in nature. We are interested in the exploration of the potential of marine natural products for the development of novel chemistry, and novel drugs. Our interests are driven by the quest for the development of GREENER APRROCHES.
Research Areas
Organic Chemistry - Target Oriented Synthesis Program (Total Synthesis of Marine Natural products (NPs), Diversity-Oriented Synthesis of NP like libraries, Heterocyclic Chemistry, Green Chemistry, Development novel methodologies, and Catalysis (enzymatic, organic,and organometallic).
Medicinal Chemistry - Drug Development Program (Elucidation of mechanism of action of Natural Products, SAR of Natural Products and Drug Discovery; Chemical biology-Elucidation of signal transduction pathways using NP libraries as probes)
Material science - Development of novel biomaterials for drug delivery, and for bioengineering
Nanotechnology - Synthesis of nanoparticles of the biomaterials for biological applications
Publications
Intramolecular Diels-Alder Chemistry of 4-Vinylimidazoles
He, Y.; Krishnamoorthy, P.; Lima, H.M.; Chen, Y.; Wu, H.; Sivappa, R.; Dias, H.V.R.; Lovely, C. J. Org. Biomol. Chem., 2011, 9, 2685-2701
Asymmetric total synthesis of ent-cyclooroidin
Mukherjee, S.; Sivappa, R.; Yousufuddin, M.; Lovely, C.J Org. Lett. 2010, 12, 4940–4943.
Efficient preparation of urocanic acid derivatives from histidine
Lovely, C.J.; Sivappa, R; Mukherjee, S.; Doundoulakis, T.; Lima, H.M.; Yousufuddin, M. Heterocycles 2010, 80, 1353-1358.
An approach to the oxazoline-containing fragments of the oroidin dimers nagelamide R and T
Mukherjee, S; Sivappa, R; Yousufuddin, M; Lovely, C. J. Synlett 2010, 5, 817-821.
Total Synthesis of the Putative Structure of Nagelamide D
Bhandari MR.; Sivappa, R.; Lovely , C.J. Org. Lett. 2009, 11, 1535-1538.
Studies toward the total synthesis of the oroidin dimers
Sivappa, R.; Mukherjee, S.; Dias, HVR.; Lovely, C.J, Org. Biomol. Chem. 2009, 7, 3215-3218.
Total Synthesis of the Leucetta-Derived Alkaloid Calcaridine A
Koswatta, P.B.; Sivappa, R.; Dias, HVR.; Lovely, C.J Synthesis2009, 2970-2982.
Total Synthesis of (±)-Calcaridine A and (±)-epi-Calcaridine A
Koswatta, P. B.; Sivappa, R.; Rasika, H, D.; Lovely, C. J. Org. Lett. 2008, 10, 5055-5058.
Studies toward the total synthesis of axinellamine and massadine
Sivappa, R.; Hernandez, N.; He, Y.; Lovely, C. J. Org. Lett. 2007, 9, 3861-3864.
Oxidative reactions of tetrahydrobenzimidazole derivatives with the N-sulfonyloxaziridines
Sivappa, R.; Koswatta, P.;Lovely, C. J. Tetrahedron Lett. 2007, 48, 5771-5775.
Preparation and Diels-Alder chemistry of 4-vinylimidazoles
Du, H.; Sivappa, R.; Bhandari, M. J.;Lovely, C. J. J. Org. Chem. 2007, 72, 3741-3749.
Silver-catalyzed [2,3]-rearrangement of halonium ylides derived from allyl and propargyl halides and diazoacetate
Pasupathy, K.; Browning, R. G.; Singh, S.; Sivappa, R.; Lovely, C. J.; Dias, H. V. R. Chem. Commun. 2007, 731-733.
Palladium-catalyzed substitution reactions of 4-allylimidazole derivatives
Pasupathy, K.; Sivappa, R.; Du, H.; Lovely, C. J. Tetrahedron 2006, 62, 10555-10566.
New methods for imidazole functionalization - from imidazole to marine alkaloids
He, Y.; Du, H.; Sivappa, R.; Lovely, C. J. Synlett 2006, 965-993.
A ring closing metathesis approach to the indole alkaloid mitralactonine
Chavan, S. P.; Sharma, P.; Sivappa, R.;Kalkote, U. R Tetrahedron Lett. 2006, 47, 9301-9303.
A convergent and facile approach towards indole alkaloid mitralactonine
Chavan, S. P.; Sharma, P.; Sivappa, R.; Kalkote, U. R. Synlett 2006, 79-82.
A metal cation complexation of a novel, doubly cage-annulated molecular box by electrospray ionization mass spectrometry
Sherman, C. L.; Brodbelt, J.; Srinivas, G.; Sivappa, R.; Marchand, A.P. ARKIVOC 2005, 3, 1-7.
Short and efficient synthesis of luotonin A, B & E
Chavan, S. P.; Sivappa, R. Tetrahedron Lett. 2004, 45, 9931-9935.
Total synthesis of nothapodytine B and (+/-)-mappicine
Chavan, S. P.; Sivappa, R. Tetrahedron Lett. 2004, 45, 3941-3943.
A synthesis of Camptothecin
Chavan, S. P.; Sivappa, R. Tetrahedron Lett. 2004, 45, 3113-3115.
A facile total synthesis of rutaecarpine
Chavan, S. P.; Sivappa, R. Tetrahedron Lett. 2004, 45, 997-999.
Regio- and stereochemistry of Michael addition studies of Thiele's diester
Minter, D.E.; Smith, W.B.; Sivappa, R.; Marchand, A.P. J. Phys. Org. Chem. 2004, 17,174-179.
Structure of a minor reaction product formed via base promoted hydrolysis of Thiele's ester
Watson, W. H.; Marchand, A.P.; Sivappa, R. ARKIVOC 2004, 3, 66-73.
Reformatsky reaction of chloroesters with carbonyl compounds with commercial zinc
Chavan, S. P.; Shivasankar, K.; Sivappa, R. J. Chem. Res. 2004, 6, 406-407.
Facile syntheses of ABC ring skeleton of camptothecin and related alkaloids
Chavan, S. P.; Sivappa, R.; Venkatraman, M. S. Synth. Commun. 2004, 34, 3099-3110.
Enantioselective synthesis of L-CCG-I
Chavan, S. P.; Sharma, P.; Sivappa, R.; Bhadbhade, M. M.; Gonnade, G.; Kalkote, U. R. J. Org. Chem. 2003, 68, 6817-6819.
Zinc mediated transesterification of b-ketoesters and coumarin synthesis
Chavan, S. P.; Shivasankar, K.; Sivappa, R.; Kale, R. Tetrahedron Lett. 2002, 43, 8583-8586
Facile synthesis of a key intermediate for the synthesis of prostanes and isoprostanes
Chavan, S. P.; Subbarao, Y.; Chittiboin, A.; Sivappa, R. Tetrahedron: Asymm. 2001, 12, 1101-03.
Transesterification of ketoesters using amberlyst-15
Chavan, S. P.; Subbarao, Y.; Dantale, S. W. Sivappa, R. Synth. Commun. 2001, 31, 281-294.
Violette 210 (508)-999-8276; Lab (508)-999-9209
Email: srasapalli@umassd.edu
WebSite: www.drrasapalli.com
