Long-term preservation of cellular and biological material is of critical in today's emerging biotechnology world. Our goal is to develop stable long-term preservation of biological materials including cellular DNA, proteins, bacteria and mammalian cells. We use cryopreservation, which is the state of the art for a majority of preservation protocols. However, cryopreservation requires storage in liquid nitrogen that can be hazardous and logistically challenging. We are also involved in extensive research on using novel excipients like sugars to develop desiccation preservation protocols. This is an emerging area of biopreservation that allows preservation at or near ambient temperatures thereby significantly simplifying the logistics of biologics based drugs to be transported to different locations.