Erin Bromage


Associate Professor

Ph.D. James Cook University, Australia 2004
Comparative Immunology

Phone: 508-999-8218 
Office: Science and Engineering, Room 327


My research interests are in broad areas of comparative immunology, but there is an emphasis in my laboratory on antibody mediated protection. Antibodies are proteins responsible for antigen (pathogen) recognition, leading to neutralization and eventual destruction of the pathogen. The highly polymorphic nature of the antibody binding domain allows them to recognize billions of different pathogens. My laboratory focuses on the structure of the antibody, the cells responsible for antibody production, and the quality of the antibody for pathogen recognition.




 Recent Publications | Graduate Students |  Courses

Current Projects

  • The role of long-lived plasma cells in immunological memory
  • Antibody secreting cell diversity following vaccination and infection
  • Modelling the adaptation of the B-cell response following Immunization



  • Guro Løkka, Lars Austbø, Knut Falk, Erin Bromage, Per Gunnar Fjelldal, Tom Hansen, Ivar Hordvik, Erling Olaf Koppang. (2014) Immune parameters in the intestine of wild and reared unvaccinated and vaccinated Atlantic salmon (Salmo salar L.). Developmental and Comparative Immunology. 47(1): 6-16
  • Castro R, Bromage E, Abós B, Pignatelli J, Granja AG, Luque A, Tafalla C. (2014) CCR7 Is Mainly Expressed in Teleost Gills, Where It Defines an IgD+IgM- B Lymphocyte Subset. Journal of Immunology. 192(3):1257-1266.
  • Ramirez-Gomez F, Greene W, Rego K, Hansen JD, Costa G, Kataria P, Bromage E. (2012) Rainbow trout utilize a novel splicing mechanism for the generation of secreted IgD.  Journal of Immunology.  183. 1341-1349
  • Purcell M, Bromage E, Silva J, Hansen J, Badil S, Woodson J, and Hershberger P.2012.  Production and Characterization of Monoclonal Antibodies to IgM of Pacific Herring (Clupea pallasii). Fish and Shellfish Immunology. 33(3):552-558.
  • Boardman T, Warner C, Gomez-Ramirez F, Matriciano J, Bromage E (2012). Characterization of anti-trout CD3e monoclonal antibodies. Veterinary Immunology and Immunopathology. 145: 511-515
  • Costa G, Danz H, Kataria P, Bromage E. (2012) A holistic view of the dynamisms of teleost IgM: A case study of Streptococcus iniae vaccinated rainbow trout (Onchorhynchus mykiss). Developmental and Comparative Immunology. 36: 298-305.
  • Ye J, Bromage E, Kaattari I, Kaattari S (2011) Transduction of binding affinity by B lymphocytes: A new dimension in immunological regulation. Developmental and Comparative Immunology 35(9):982-90
  • Carpenter L, Patterson M, Bromage E (2010) Water flow influences the spatiotemporal distribution of heat shock protein 70 within colonies of the coral Montastrea annularis. Journal of Experimental Marine Biology and Ecology. 387: 52-59.
  • Ye J, Bromage E, Kaattari S (2010). The strength of B cell interaction with antigen determines the degree of IgM polymerization. Journal of Immunology. 184: 844-850
  • Bromage E, Stephens R, Hassoun L (2009). The third dimension of ELISPOTS; quantifying antibody secretion from individual trout plasma cells. Journal of Immunological Methods 346; 75-79.
  • Bromage E and Owens L (2009). Environmental factors affecting the susceptibility of barramundi to Streptococcus iniae. Aquaculture. 290: 224-228.
  • Spier C, Bromage E, Harris T, Unger M, Kaattari S (2009). The development and evaluation of monoclonal antibodies for the detection of polycyclic aromatic hydrocarbons. Analytical Biochemistry. 387: 287-293.
  • Bromage E, Carpenter L, Kaattari S, Patterson M (2009). Quantification of coral heat shock proteins from individual coral polyps. Marine Ecology Progress Series 376:123-132
  • Bromage E, Long C, Kaattari S (2008).  Biomarkers of oogenesis in Macoma balthica determined by subtractive immunization. Aquatic Biology 3: 139-145
  • Long C, Bromage E, Seitz R, Kaattari S (2008). Quantifying fecundity in Macoma balthica using an enzyme-linked immunosorbent assay (ELISA). Aquatic Biology 3: 187-193.
  • Kaattari S, Brown G, Kaattari I, Ye J, Haines A, Bromage E (2008). The Cellular and Developmental Biology of the Teleost Antibody Response. In: Fish Defenses Vol I Immunology (Science Publishers, New Hampshire; Eds. Zaccone, Secombes, Manning, Kapoor).
  • Bromage E, Vadas G, Harvey E, Unger M, Kaattari S (2007). Validation of an Antibody-Based Biosensor for Rapid Quantification of 2,4,6-Trinitrotoluene (TNT) Contamination in Ground Water and River Water. Environmental Science and Technology. 41(20):7067-72
  • Bromage E, Kaattari S (2007). Simultaneous quantitative analysis of multiple protein species within a single sample using standard scanning densitometry. J Immunol Methods,  323: 109-113
  • Bromage E, Lackie T, Unger MA, Ye J, Kaattari SL (2007) The development of a real-time biosensor for the detection of trace levels of trinitrotoluene (TNT) in aquatic environments.  Biosens Bioelect. 22: 2532-38
  • Bromage E, Ye J, Kaattari S. 2006. Antibody structural variation in rainbow trout fluids. Comp Biochem Physiol Part B. 143: 61-69.
  • Zwollo P, Cole S, Bromage E, Kaattari S (2005) Physical and serological analyses of B cell populations in immune tissues of the rainbow trout. J Immunol  174: 6608-6616. 
  • Kaattari S, Bromage E, Kaattari I (2005) Analysis of Long-lived Plasma Cell Production and Regulation: Implications for Vaccine Design for Aquaculture. Aquaculture 246: 1-9. 
  • Bromage E, Kaattari I, Zwollo P, Kaattari S (2004) Plasmablast and Plasma Cell Production and Distribution in Trout Immune Tissues. J Immunol 173(12). 7317-7323
  • Bromage E S, Ye J, Owens L, Kaattari I, Kaattari S (2004) Use of Staphylococcal Protein A in the Analysis of Teleost Immunoglobulin Structural Diversity. Dev Comp Immunol 28. 803-814. 
  • Munro J, Oakey J, Bromage E, Owens L (2003). Experimental bacteriophage-mediated virulence in strains of Vibrio harveyi. Dis Aqua Org. 54: 187-194. 
  • Bromage E S and Owens L (2002). Infection of barramundi Lates calcarifer with Streptococcus iniae: effects of different routes of exposure. Dis Aqua Org52: 199-205.
  • Cimino E J, Owens L, Bromage E, Anderson T A (2002) A newly developed ELISA showing the effect of environmental stress on levels of hsp86 in Cherax quadricarinatus and Penaeus monodon. Comp Biochem Physiol. 132A(3):  591-598.
  • Bromage E S, Thomas A, Owens L (1999) Streptococcus iniae, a bacterial infection in barramundi, Lates calcarifer. Dis Aqua Org. 36: 177-181

Graduate Students

PhD Students

Abigail Toltin         

Masters Students

Annie Poirier            

Danielle Dupras      



Courses Professor Bromage has taught include:

BIO 310 Infection and Immunology

BIO 420 Immunology

BIO 411/511 Comparative Immunology


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