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CATEGORIES:College of Arts and Sciences,Thesis/Dissertations
DESCRIPTION:Title: Single-Particle Chiral Spectromicroscopy:Artifact Correc
 tion and Characterization of Plasmonic Nanostructures by Vidhi Singla Advi
 sor:  Dr. Wei-Shun Chang, Chemistry & Biochemistry Dept. Committee Member
 s: Dr. Catherine Neto, Chemistry & Biochemistry Dept. & Dr. Milana Vasudev
 , Bioengineering Dept. Abstract: Chirality plays a critical role in biolog
 y and medicine, yet conventional techniques such as optical rotatory dispe
 rsion and circular dichroism suffer from low detection sensitivity. Plasmo
 nic nanostructures enhance chirality detection through localized surface p
 lasmon resonance, but their inherent size and shape heterogeneity makes si
 ngle-particle measurements essential. Existing single-particle dark-field 
 scattering methods, however, suffer from linear dichroism artifacts caused
  by imperfect waveplate retardance, resulting in ±10% measurement uncerta
 inty. This thesis develops an artifact-free single-particle chiral dark-fi
 eld scattering spectromicroscopy. Using unpolarized excitation and a quart
 er-wave plate/Wollaston prism detection assembly, left- and right-handed c
 ircularly polarized scattering are simultaneously decoded. Dual measuremen
 ts at ±45° waveplate orientations eliminate linear dichroism artifacts w
 hile preserving true chiral signals, verified by Stokes–Mueller calculus
 . The method enables accurate, high-throughput chirality characterization 
 without modifying existing instrumentation.\nEvent page: https://www.umass
 d.edu/events/cms/ms-thesis-defense-by-vidhi-singla.php\nEvent link: https:
 //umassd.zoom.us/j/91017390345?pwd=gAgrVmNcwf0aeGTwbjVTtTskMjJVlP.1
X-ALT-DESC;FMTTYPE=text/html:<html><body><p>Title: Single-Particle Chiral S
 pectromicroscopy:Artifact Correction and Characterization of Plasmonic Nan
 ostructures by Vidhi Singla</p>\n<p>Advisor:  Dr. Wei-Shun Chang\, Chemis
 try & Biochemistry Dept.</p>\n<p>Committee Members: Dr. Catherine Neto\, C
 hemistry & Biochemistry Dept. & Dr. Milana Vasudev\, Bioengineering Dept.<
 /p>\n<p>Abstract:</p>\n<p>Chirality plays a critical role in biology and m
 edicine\, yet conventional techniques such as optical rotatory dispersion 
 and circular dichroism suffer from low detection sensitivity. Plasmonic na
 nostructures enhance chirality detection through localized surface plasmon
  resonance\, but their inherent size and shape heterogeneity makes single-
 particle measurements essential. Existing single-particle dark-field scatt
 ering methods\, however\, suffer from linear dichroism artifacts caused by
  imperfect waveplate retardance\, resulting in ±10% measurement uncertain
 ty.</p>\n<p>This thesis develops an artifact-free single-particle chiral d
 ark-field scattering spectromicroscopy. Using unpolarized excitation and a
  quarter-wave plate/Wollaston prism detection assembly\, left- and right-h
 anded circularly polarized scattering are simultaneously decoded. Dual mea
 surements at ±45° waveplate orientations eliminate linear dichroism arti
 facts while preserving true chiral signals\, verified by Stokes–Mueller 
 calculus. The method enables accurate\, high-throughput chirality characte
 rization without modifying existing instrumentation.</p><p>Event page: <a 
 href="https://www.umassd.edu/events/cms/ms-thesis-defense-by-vidhi-singla.
 php">https://www.umassd.edu/events/cms/ms-thesis-defense-by-vidhi-singla.p
 hp</a><br>Event link: <a href="https://umassd.zoom.us/j/91017390345?pwd=gA
 grVmNcwf0aeGTwbjVTtTskMjJVlP.1">https://umassd.zoom.us/j/91017390345?pwd=g
 AgrVmNcwf0aeGTwbjVTtTskMjJVlP.1</a></p></body></html>
DTSTAMP:20260602T134846
DTSTART;TZID=America/New_York:20260615T130000
DTEND;TZID=America/New_York:20260615T150000
LOCATION:Virtual
SUMMARY;LANGUAGE=en-us:MS Thesis Defense by Vidhi Singla
UID:c3aa4c816ef46d239ebd93eca1cd12c9@www.umassd.edu
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