BEGIN:VCALENDAR VERSION:2.0 X-WR-CALNAME:EventsCalendar PRODID:-//hacksw/handcal//NONSGML v1.0//EN CALSCALE:GREGORIAN BEGIN:VTIMEZONE TZID:America/New_York LAST-MODIFIED:20240422T053451Z TZURL:https://www.tzurl.org/zoneinfo-outlook/America/New_York X-LIC-LOCATION:America/New_York BEGIN:DAYLIGHT TZNAME:EDT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 DTSTART:19700308T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZNAME:EST TZOFFSETFROM:-0400 TZOFFSETTO:-0500 DTSTART:19701101T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT CATEGORIES:College of Arts and Sciences,Thesis/Dissertations DESCRIPTION:Advisor: Professor David Manke Committee Members: Professor Cat herine Neto and Professor Shuowei Cai Abstract: Tryptamine natural product s, particularly serotonin, play important physiological roles and function as a neurotransmitter in mediating mood in humans through their interacti ons with serotonin receptors, which are distributed throughout the central andperipheral nervous systems. While serotonin controls mood in the centr al nervous system, a vast majority of it is found in peripheral locations. There are many tryptamine natural products found in nature, including a v ariety of compounds that are maximally alkylated to generate quaternary tr yptamines, which, due to their charged nature, are unlikely to cross the b lood-brain barrier. What (if any) role do these peripherally restricted co mpounds play? In this research work, novel analogues of quaternary tryptam monium salts are synthesized and characterized using NMR and single-crysta l X-ray crystallography to advance the understanding of their impact. \nE vent page: https://www.umassd.edu/events/cms/7-20-26-ms-thesis-defense-by- harsh-bawa.php X-ALT-DESC;FMTTYPE=text/html:

Advisor: Professor David Manke< /p>\n

Committee Members: Professor Catherine Neto and Professor Shuowei Cai

\n

Abstract: Tryptamine natural products\, particularly serotonin \, play important physiological roles and function as a neurotransmitter i n mediating mood in humans through their interactions with serotonin recep tors\, which are distributed throughout the central and
peripheral ne rvous systems. While serotonin controls mood in the central nervous system \, a vast majority of it is found in peripheral locations. There are many tryptamine natural products found in nature\, including a variety of compo unds that are maximally alkylated to generate quaternary tryptamines\, whi ch\, due to their charged nature\, are unlikely to cross the blood-brain b arrier. What (if any) role do these peripherally restricted compounds play ?

\n

In this research work\, novel analogues of quaternary tryptammon ium salts are synthesized and characterized using NMR and single-crystal X -ray crystallography to advance the understanding of their impact. 

Event page: https://www.umassd.edu/events/cms/7-20-26-ms-th esis-defense-by-harsh-bawa.php

DTSTAMP:20260629T164614 DTSTART;TZID=America/New_York:20260720T100000 DTEND;TZID=America/New_York:20260720T120000 LOCATION:CCB-341 SUMMARY;LANGUAGE=en-us:MS Thesis Defense by Harsh Bawa UID:a98e4c1a71398f65af24fa955c34dd3d@www.umassd.edu END:VEVENT END:VCALENDAR