BEGIN:VCALENDAR VERSION:2.0 X-WR-CALNAME:EventsCalendar PRODID:-//hacksw/handcal//NONSGML v1.0//EN CALSCALE:GREGORIAN BEGIN:VTIMEZONE TZID:America/New_York LAST-MODIFIED:20240422T053451Z TZURL:https://www.tzurl.org/zoneinfo-outlook/America/New_York X-LIC-LOCATION:America/New_York BEGIN:DAYLIGHT TZNAME:EDT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 DTSTART:19700308T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZNAME:EST TZOFFSETFROM:-0400 TZOFFSETTO:-0500 DTSTART:19701101T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT CATEGORIES:College of Arts and Sciences,Thesis/Dissertations DESCRIPTION:Title: Studies Toward Diverse Tricyclic Heterocycles Through Le wis Acid-Promoted Aza-Nazarov Cyclization by thamanna Begum Advisor: Dr. Sivappa Rasapalli, Chemistry & Biochemistry Dept. Committee Members:  D r. Shuowei Cai, Chemistry & Biochemistry Dept. Dr. Wei-Shun Chang, Chemist ry & Biochemistry Dept. Abstract: Polycyclic alkaloids are valued structur es which are sought after in drug discovery for their bulky, rigid nature and their wide range of pharmaceutical applications. Already found in natu re, these compounds exhibit antimicrobial, antifungal, and antitumor prope rties, which attract interest due to their potential in medicinal chemistr y. Being able to synthesize and redesign these molecules is an advantage t o optimize selectivity and precise binding to specific biological substrat es. However, conventional approaches to these architecturally complex fram eworks demand extensive experimental steps with low yields, limiting acces s to structural diversity. This research employs the Aza-Nazarov cyclizati on reaction to fold varying alkaloid precursors into tricyclic heterocycle s with great diversity in a single acid-catalyzed step. Precursors contain ing indole, benzimidazole, and imidazo[1,2- α]pyrimidine cores with diffe rent substituents were synthesized, featuring either typical Nazarov conju gated systems or α-ketoamides that serve as double-bond equivalents. Thes e were then subjected to a variety of Lewis acids in different conditions, including solvent systems, temperatures, and addition of catalysts, to pr omote ring closure with NMR and X-ray crystallography for structure determ ination. Optimizations of reaction conditions for improved purity and high er yield are ongoing. This thesis serves a purpose to extend the synthetic scope of Aza-Nazarov cyclization across multiple alkaloid frameworks, ena bling easier access to bioactive compounds with pharmacological prospectiv es.\nEvent page: https://www.umassd.edu/events/cms/8-5-26-thamanna-begum-s tudies-toward-diverse-tricyclic-heterocycles.php X-ALT-DESC;FMTTYPE=text/html:

Title: Studies Toward Diverse T ricyclic Heterocycles Through Lewis Acid-Promoted Aza-Nazarov Cyclization by thamanna Begum

Advisor: Dr. Sivappa Rasapalli\, Chemistry & Biochemistry Dept.

Committ ee Members: 

Dr. Shuowei Cai\, Chemistry & Biochemistry Dept.

Dr. Wei-Shun Chang\, Chemistry & Biochemistry Dept.

Abstract:

Polycycl ic alkaloids are valued structures which are sought after in drug discover y for their bulky\, rigid nature and their wide range of pharmaceutical ap plications. Already found in nature\, these compounds exhibit antimicrobia l\, antifungal\, and antitumor properties\, which attract interest due to their potential in medicinal chemistry. Being able to synthesize and redes ign these molecules is an advantage to optimize selectivity and precise bi nding to specific biological substrates. However\, conventional approaches to these architecturally complex frameworks demand extensive experimental steps with low yields\, limiting access to structural diversity. This res earch employs the Aza-Nazarov cyclization reaction to fold varying alkaloi d precursors into tricyclic heterocycles with great diversity in a single acid-catalyzed step. Precursors containing indole\, benzimidazole\, and im idazo[1\,2- α]pyrimidine cores with different substituents were synthesiz ed\, featuring either typical Nazarov conjugated systems or α-ketoamides that serve as double-bond equivalents. These were then subjected to a vari ety of Lewis acids in different conditions\, including solvent systems\, t emperatures\, and addition of catalysts\, to promote ring closure with NMR and X-ray crystallography for structure determination. Optimizations of r eaction conditions for improved purity and higher yield are ongoing. This thesis serves a purpose to extend the synthetic scope of Aza-Nazarov cycli zation across multiple alkaloid frameworks\, enabling easier access to bio active compounds with pharmacological prospectives.

Event page: https://www.umassd.edu/events/cms/8- 5-26-thamanna-begum-studies-toward-diverse-tricyclic-heterocycles.php< /a>

DTSTAMP:20260716T170056 DTSTART;TZID=America/New_York:20260805T130000 DTEND;TZID=America/New_York:20260805T150000 LOCATION:VRB-210 SUMMARY;LANGUAGE=en-us:Studies Toward Diverse Tricyclic Heterocycles Throug h Lewis Acid-Promoted Aza-Nazarov Cyclization UID:e439dd6ea398df13e0db08d1660fd226@www.umassd.edu END:VEVENT END:VCALENDAR