BEGIN:VCALENDAR VERSION:2.0 X-WR-CALNAME:EventsCalendar PRODID:-//hacksw/handcal//NONSGML v1.0//EN CALSCALE:GREGORIAN BEGIN:VTIMEZONE TZID:America/New_York LAST-MODIFIED:20240422T053451Z TZURL:https://www.tzurl.org/zoneinfo-outlook/America/New_York X-LIC-LOCATION:America/New_York BEGIN:DAYLIGHT TZNAME:EDT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 DTSTART:19700308T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZNAME:EST TZOFFSETFROM:-0400 TZOFFSETTO:-0500 DTSTART:19701101T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT CATEGORIES:Thesis/Dissertations DESCRIPTION:Title: Synthesis and Structural Characterization of Halogen-Sub stituted Tryptamine Derivatives Bearing Bulky N-Alkyl Substituents Advisor : Dr. David Manke, Chemistry & Biochemistry Dept. Committee Members: D r. Shuowei Cai, Chemistry & Biochemistry Dept.; Dr. Olusegun B. Olubanwo, Chemistry & Biochemistry Dept. Abstract: Tryptamines are widely distribute d in nature and include biologically important molecules such as serotonin , together with naturally occurring N,N-dialkylated compounds including DM T, 5-MeO-DMT, and bufotenine. Halogenated tryptamines, such as 5-bromo-DMT and 5-chloro-DMT, have also been identified in marine organisms, illustra ting how relatively small structural modifications contribute to the remar kable chemical diversity of this family. More recently, the clinical devel opment of bretisilocin (GM-2505; 5-fluoro-N-methyl-N-ethyltryptamine) to t reat major depressive disorder has renewed interest in understanding how s tructural modification of the halogenated tryptamine scaffold influences b iological activity. These developments highlight the importance of underst anding how halogen substitution and N-alkyl group steric bulk influence th e chemical behavior and structural properties of tryptamine derivatives. T o investigate these effects, series of halogen-substituted N-isopropyltryp tammonium (NIPT), N,N-diisopropyltryptammonium (DiPT), and N,N,N-tributylt ryptammonium iodide (TBTI) derivatives were synthesized and characterized using multinuclear NMR spectroscopy and single-crystal X-ray diffraction. This work expands the structural chemistry of halogenated tryptamine deriv atives and provides a foundation for future biological and structure–act ivity relationship investigations.\nEvent page: https://www.umassd.edu/eve nts/cms/8-3-26-synthesis-and-structural-characterization-of-halogen-substi tuted-tryptami.php X-ALT-DESC;FMTTYPE=text/html:

Title: Synthesis and Structural Characterization of Halogen-Substituted Tryptamine Derivatives Bearing Bu lky N-Alkyl Substituents

Advisor: Dr. David Manke\, Chemistry & Bi ochemistry Dept.

Committee Members: Dr. Shuowei Cai\, Chemistr y & Biochemistry Dept.\; Dr. Olusegun B. Olubanwo\, Chemistry & Biochemist ry Dept.

Abstract:

Tryptamines are widely distributed in n ature and include biologically important molecules such as serotonin\, tog ether with naturally occurring N\,N-dialkylated compounds including DMT\, 5-MeO-DMT\, and bufotenine. Halogenated tryptamines\, such as 5-bromo-DMT and 5-chloro-DMT\, have also been identified in marine organisms\, illustr ating how relatively small structural modifications contribute to the rema rkable chemical diversity of this family. More recently\, the clinical dev elopment of bretisilocin (GM-2505\; 5-fluoro-N-methyl-N-ethyltryptamine) t o treat major depressive disorder has renewed interest in understanding ho w structural modification of the halogenated tryptamine scaffold influence s biological activity. These developments highlight the importance of unde rstanding how halogen substitution and N-alkyl group steric bulk influence the chemical behavior and structural properties of tryptamine derivatives . To investigate these effects\, series of halogen-substituted N-isopropyl tryptammonium (NIPT)\, N\,N-diisopropyltryptammonium (DiPT)\, and N\,N\,N- tributyltryptammonium iodide (TBTI) derivatives were synthesized and chara cterized using multinuclear NMR spectroscopy and single-crystal X-ray diff raction. This work expands the structural chemistry of halogenated tryptam ine derivatives and provides a foundation for future biological and struct ure–activity relationship investigations.

Event page: https://www.umassd.edu/events/c ms/8-3-26-synthesis-and-structural-characterization-of-halogen-substituted -tryptami.php

DTSTAMP:20260716T170056 DTSTART;TZID=America/New_York:20260803T130000 DTEND;TZID=America/New_York:20260803T140000 LOCATION:CCB 341 SUMMARY;LANGUAGE=en-us:Synthesis and Structural Characterization of Halogen -Substituted Tryptamine Derivatives Bearing Bulky N-Alkyl Substituents UID:ac1864c68a779a8c38b3a0d5244c11bb@www.umassd.edu END:VEVENT END:VCALENDAR