BEGIN:VCALENDAR VERSION:2.0 X-WR-CALNAME:EventsCalendar PRODID:-//hacksw/handcal//NONSGML v1.0//EN CALSCALE:GREGORIAN BEGIN:VTIMEZONE TZID:America/New_York LAST-MODIFIED:20240422T053451Z TZURL:https://www.tzurl.org/zoneinfo-outlook/America/New_York X-LIC-LOCATION:America/New_York BEGIN:DAYLIGHT TZNAME:EDT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 DTSTART:19700308T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZNAME:EST TZOFFSETFROM:-0400 TZOFFSETTO:-0500 DTSTART:19701101T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT CATEGORIES:College of Engineering,Thesis/Dissertations DESCRIPTION:Biomedical Engineering & Biotechnology BMEBT MS Thesis Proposal Presentation by Jacob BurrerDate: September 4, 2026Time: 12 PMLocation: T EX 011 Title: Location Based Impacts of Glycation on The Mechanical Proper ties of Human Cortical Bone Abstract: Understanding bone composition and s tructure, as well as the processes involved in bone formation, is essentia l for predicting fracture risk and morphology in a wide variety of patient groups. Some of the factors that contribute to an increased risk of bone fracture include the propensity to fall, changes in bone mineral density, and reduced bone quality. One of the ways in which bone matrix quality can be significantly altered is through a process called non-enzymatic glycat ion. This process leads to the formation of advanced glycation end product s (AGEs), which can negatively impact bone matrix quality in a variety of ways. Although the effect that AGE accumulation has on bone matrix quality is well documented, there is less information on how AGE content affects specific regions of bone based on anatomical position. To assess how glyca tion affects specific regions of bone tissue, bone samples will be collect ed and incubated to simulate in vivo hyperglycemic conditions. These sampl es will then be mechanically tested to determine how the mechanical proper ties of specific bone regions change after accumulating AGEs. The total am ount of AGE accumulation will also be quantified using a spectrophotometri c assay to determine which regions of bone have the highest concentration of AGEs after glycation. Results from this project could lead to the devel opment of diagnostic tools that can predict future fractures based on AGE content and medical interventions that can prevent or reduce the risk of f ractures for certain patient groups. Advisor: Dr. Lamya Karim, Dept. of Bi oengineering (lkarim@umassd.edu) Committee Members: Dr. Tracie Ferreira, Dept. of Bioengineering Dr. Laura Hanzly, Dept. of Bioengineering All BME BT graduate students are encouraged to attend, and all interested parties are invited.\nEvent page: https://www.umassd.edu/events/cms/9-4-26-bmebt-m s-thesis-proposal-presentation-by-jacob-burrer.php X-ALT-DESC;FMTTYPE=text/html:

Biomedical Engineering & Biotec hnology

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BMEBT MS Thesis Proposal Presentation by Jacob Burrer
Date: September 4\, 2026
Time: 12 PM
Location: TEX 011

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Title: Location Based Impacts of Glycation on The Mechanical Properties of Human Cortical Bone

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Abstract: Understanding bone composition and structure\, as well as the processes involved in bone formation\, is essen tial for predicting fracture risk and morphology in a wide variety of pati ent groups. Some of the factors that contribute to an increased risk of bo ne fracture include the propensity to fall\, changes in bone mineral densi ty\, and reduced bone quality. One of the ways in which bone matrix qualit y can be significantly altered is through a process called non-enzymatic g lycation. This process leads to the formation of advanced glycation end pr oducts (AGEs)\, which can negatively impact bone matrix quality in a varie ty of ways. Although the effect that AGE accumulation has on bone matrix q uality is well documented\, there is less information on how AGE content a ffects specific regions of bone based on anatomical position. To assess ho w glycation affects specific regions of bone tissue\, bone samples will be collected and incubated to simulate in vivo hyperglycemic conditions. The se samples will then be mechanically tested to determine how the mechanica l properties of specific bone regions change after accumulating AGEs. The total amount of AGE accumulation will also be quantified using a spectroph otometric assay to determine which regions of bone have the highest concen tration of AGEs after glycation. Results from this project could lead to t he development of diagnostic tools that can predict future fractures based on AGE content and medical interventions that can prevent or reduce the r isk of fractures for certain patient groups.

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Advisor: Dr. Lamya Ka rim\, Dept. of Bioengineering (lkarim@umassd.edu)

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Committee Member s:

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All BMEBT gradu ate students are encouraged to attend\, and all interested parties are inv ited.

Event page: https://www.uma ssd.edu/events/cms/9-4-26-bmebt-ms-thesis-proposal-presentation-by-jacob-b urrer.php

DTSTAMP:20260814T151048 DTSTART;TZID=America/New_York:20260904T120000 DTEND;TZID=America/New_York:20260904T130000 LOCATION:TEX 011 SUMMARY;LANGUAGE=en-us:BMEBT MS Thesis Proposal Presentation by Jacob Burre r UID:8ad585ef0051d63cd5be87253beea78c@www.umassd.edu END:VEVENT END:VCALENDAR