BEGIN:VCALENDAR VERSION:2.0 X-WR-CALNAME:EventsCalendar PRODID:-//hacksw/handcal//NONSGML v1.0//EN CALSCALE:GREGORIAN BEGIN:VTIMEZONE TZID:America/New_York LAST-MODIFIED:20240422T053451Z TZURL:https://www.tzurl.org/zoneinfo-outlook/America/New_York X-LIC-LOCATION:America/New_York BEGIN:DAYLIGHT TZNAME:EDT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 DTSTART:19700308T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZNAME:EST TZOFFSETFROM:-0400 TZOFFSETTO:-0500 DTSTART:19701101T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT CATEGORIES:College of Arts and Sciences,College of Engineering,Thesis/Disse rtations DESCRIPTION:Abstract Melanoma remains a highly aggressive malignancy in whi ch therapeutic resistance and recurrence are partly driven by cancer stem- like cells (CSCs). This research proposes a multifunctional lipid–polyme r hybrid nanoparticle platform co-loading cisplatin, honokiol, and indocya nine green (ICG) to integrate chemotherapy, natural-product-based therapy, and near-infrared (NIR)-responsive photothermal treatment. Using SK-MEL-2 8 melanoma spheroids as a three-dimensional model enriched in stem-like ch aracteristics, the study will investigate treatment-induced cytotoxicity, reactive oxygen species generation, and changes in CSC-associated markers, including CD133, CD271, and ABCB5. Particular emphasis will be placed on determining whether controlled ROS generation can modulate CSC fate while enhancing therapeutic response. This work aims to establish a multifunctio nal strategy for targeting both bulk melanoma cells and stem-like populati ons, with the long-term goal of overcoming therapeutic resistance and redu cing tumor recurrence. ADVISORS:   Dr. Tracie Ferreira, Department of Bi oengineering (tferreira@umassd.edu) Dr. Kihan Park, Department of Mechanic al Engineering (kpark1@umassd.edu) COMMITTEE MEMBERS:       Dr. Racha el Siriani, Department of Neurological Surgery, University of Massachusett s Chan Medical School Dr. Lamya Karim, Department of Bioengineering, UMass D Dr. Milana Vasudev, Department of Bioengineering, UMassD                                      NOTE: All Bioengineering Student s are ENCOURAGED to attend.\nEvent page: https://www.umassd.edu/events/cms /9-29-26-bmebt-doctoral-proposal-defense-by-kosar-fateh.php\nEvent link: h ttps://us05web.zoom.us/j/84126380042?pwd=5bxJk3kSM3rZj1mNsaPSV2kwPbUxQm.1 X-ALT-DESC;FMTTYPE=text/html:

Abstract

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Melanoma remai ns a highly aggressive malignancy in which therapeutic resistance and recu rrence are partly driven by cancer stem-like cells (CSCs). This research p roposes a multifunctional lipid–polymer hybrid nanoparticle platform co- loading cisplatin\, honokiol\, and indocyanine green (ICG) to integrate ch emotherapy\, natural-product-based therapy\, and near-infrared (NIR)-respo nsive photothermal treatment. Using SK-MEL-28 melanoma spheroids as a thre e-dimensional model enriched in stem-like characteristics\, the study will investigate treatment-induced cytotoxicity\, reactive oxygen species gene ration\, and changes in CSC-associated markers\, including CD133\, CD271\, and ABCB5. Particular emphasis will be placed on determining whether cont rolled ROS generation can modulate CSC fate while enhancing therapeutic re sponse. This work aims to establish a multifunctional strategy for targeti ng both bulk melanoma cells and stem-like populations\, with the long-term goal of overcoming therapeutic resistance and reducing tumor recurrence.< /p>\n

ADVISORS:  

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COMMITTEE ME MBERS:      

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NOTE: All Bioengineering Students are ENCOURAGED to attend.

Event page: https://www.umassd.edu/events/cms/9-29-26-bmebt-doctoral-proposal- defense-by-kosar-fateh.php
Event link: https://us05web.z oom.us/j/84126380042?pwd=5bxJk3kSM3rZj1mNsaPSV2kwPbUxQm.1

DTSTAMP:20260918T233830 DTSTART;TZID=America/New_York:20260929T130000 DTEND;TZID=America/New_York:20260929T140000 LOCATION:Textile 219 SUMMARY;LANGUAGE=en-us:BMEBT Doctoral Proposal Defense by Kosar Fateh UID:84da375a66c294e5639cfeceedec35c8@www.umassd.edu END:VEVENT END:VCALENDAR