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CATEGORIES:Uncategorized
DESCRIPTION:Trypanosomatids cause a range of deadly diseases, including Hum
 an African Trypanosomiasis (HAT), Chagas, and Kala-azar, which impact mill
 ions of people worldwide. These parasites undergo significant changes to t
 heir cell morphology to adapt to the varying environments they encounter w
 ithin their mammalian hosts and insect vectors. A sheet of microtubules, k
 nown as the subpellicular microtubule array, underlies the parasite plasma
  membrane and drives cell morphogenesis. Very little is known about how th
 e subpellicular array is organized and duplicated during cell division, pa
 rtly because the tight arrangement of the microtubules and their helical t
 wist make it difficult to image the array in its entirety. The molecular c
 omponents of the array also remain uncharacterized. Using a range of bioch
 emical and imaging approaches, we have now created the first reconstructio
 ns of full subpellicular microtubule arrays in Trypanosoma brucei, the cau
 sative agent of HAT. These reconstructions provide key information about h
 ow the subpellicular array shapes these parasites and how it is inherited 
 during cell division, exemplifying how highly divergent parasites have spe
 cialized components of the core eukaryotic toolkit to suit their specific 
 needs, selected by a very different evolutionary trajectory than that of b
 etter-studied organisms. These uniquely configured pathways could be poten
 tial avenues for drug discovery, which is sorely needed.\nEvent page: http
 s://www.umassd.edu/events/cms/11-4-26-biology-seminar-by-christopher-de-gr
 affenried-brown-university.php
X-ALT-DESC;FMTTYPE=text/html:<html><body><p>Trypanosomatids cause a range o
 f deadly diseases\, including Human African Trypanosomiasis (HAT)\, Chagas
 \, and Kala-azar\, which impact millions of people worldwide. These parasi
 tes undergo significant changes to their cell morphology to adapt to the v
 arying environments they encounter within their mammalian hosts and insect
  vectors. A sheet of microtubules\, known as the subpellicular microtubule
  array\, underlies the parasite plasma membrane and drives cell morphogene
 sis. Very little is known about how the subpellicular array is organized a
 nd duplicated during cell division\, partly because the tight arrangement 
 of the microtubules and their helical twist make it difficult to image the
  array in its entirety. The molecular components of the array also remain 
 uncharacterized. Using a range of biochemical and imaging approaches\, we 
 have now created the first reconstructions of full subpellicular microtubu
 le arrays in Trypanosoma brucei\, the causative agent of HAT. These recons
 tructions provide key information about how the subpellicular array shapes
  these parasites and how it is inherited during cell division\, exemplifyi
 ng how highly divergent parasites have specialized components of the core 
 eukaryotic toolkit to suit their specific needs\, selected by a very diffe
 rent evolutionary trajectory than that of better-studied organisms. These 
 uniquely configured pathways could be potential avenues for drug discovery
 \, which is sorely needed.</p><p>Event page: <a href="https://www.umassd.e
 du/events/cms/11-4-26-biology-seminar-by-christopher-de-graffenried-brown-
 university.php">https://www.umassd.edu/events/cms/11-4-26-biology-seminar-
 by-christopher-de-graffenried-brown-university.php</a></a></p></body></htm
 l>
DTSTAMP:20261030T003845
DTSTART;TZID=America/New_York:20261106T120000
DTEND;TZID=America/New_York:20261106T125000
LOCATION:SENG113
SUMMARY;LANGUAGE=en-us:Biology Seminar by Christopher de Graffenried (Brown
  University)
UID:5c5cd57cd97f2b73e1277f6b7deffd97@www.umassd.edu
END:VEVENT
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