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Small Research Grant Program for the Next Generation of Researchers in Alzheimer's Disease 

Agency: National Institute of Health/ National Institute on Aging (Department of Health and Human Services)

Discipline: Basic Science, Biology

Funding                                                  Sponsor Deadline

$200,00                                                  Proposal: 2/16/2020 (5:00 PM local time of applicant organization)

Response for Proposal

The overall goal of this FOA is to support innovative research projects that utilize a systems biology approach to identify, model, and predict the architecture and dynamics of the molecular interactions underlying the pathogenesis of AD/ADRD. Companion FOAs (PAS-19-391 and PAS-19-392) focus on 1) secondary data analysis and health disparities and 2) basic science approaches to elucidate neurodegenerative mechanisms/pathways. NIA expects that at least half of the awards will be made to ESIs in order to meet the goal of fostering their development.

Projects could cover a wide array of topics including, but not limited to, the following:

Determination of biological processes and molecular pathways that are associated with disease initiation, progression, or outcome Identification and validation of molecular and regulatory interaction networks that may be used to explain or predict risk of, severity of, or protection from ADRD

The systems biology approach consists of repeated cycles of experimental data generation, analysis, and integration; modeling of system-wide molecular network structure and dynamics; and validation through predictions of responses to perturbations of experimental conditions or alteration of selected components of the network. Use of omics and other types of data from existing molecular profiling studies is strongly encouraged. Development of innovative computational approaches for integration of multiple data types generated by high throughput experimental technologies could be supported if justified appropriately.

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