Intersession ends, intersession finals
Intersession ends, intersession finals
First Day of Classes
Spring classes begin today.
Last day to Add, Drop, or Audit
Today is the last day to add/drop a class. Today is the last day to audit a class.
BMEBT DISSERTATION PROPOSAL PRESENTATION
The Biomedical Engineering and Biotechnology (BMEBT) Program is pleased to announce a dissertation proposal presentation by AJ Vincelli. Snacks will be provided. Proposal Title: Engineering a Platform Technology to Incorporate a Fluorescent Amino Acid into Proteins for Live-Cell Imaging of Mistrafficking Events Abstract: Thousands of diseases are thought to be caused by genetic mutations and subsequent aberrant protein localization within the cell, though pathological mechanisms are understood for only a fraction of all known mutations. This project aims to engineer a widely-applicable platform which can visualize real-time protein trafficking events in living human cells. First, a mutant library of yeast tryptophanyl-tRNA synthetases (RS) will be rationally designed to recognize a small coumarin fluorescent amino acid. The yeast enzyme is thought to be orthogonal to human tryptophan aminoacylation processes, yet still recognizable to the mammalian cell's translational machinery. Second, a cognate yeast amber suppressor coumarinyl tRNA will also be engineered, which will be charged with free coumarin amino acid by the RS. When cloned into a vector and transfected into human cells, these engineered biomolecules will insert the small coumarin fluorescent amino acid into a desired position within a protein of interest without perturbing its native structure or function. After confirming platform functionality in human cells using a GFP reporter assay, this technology will be applied to a proof-of-concept mistrafficking disease model. A single missense mutation in the protein of interest abolishes its localization signal, and thus it accumulates in the incorrect cellular compartment and causes disease. Both the wild-type protein trafficking, as well as mutant protein localization, will be visualized in real time using confocal microscopy. This proposed novel platform technology has broad applicability to protein localization studies which can reveal the pathogenesis of mistrafficking pathways, validate suspected mistrafficking mutations, and enable a greater understanding of disease-related phenotypes at the subcellular level. Location: SENG-311 RSVP To: AJ Vincelli, firstname.lastname@example.org (please RSVP, so we know how much food to bring!) Advisor: Dr. Maolin Guo Committee Members: Dr. Tracie Ferreira, Dr. Xiaofei Jia, and Dr. Firas Khatib
16th Annual Dr. Martin Luther King, Jr. Breakfast
Featuring keynote speaker Shaun King, American writer and civil rights activist. Through a mastery of social media, Shaun King starts and extends crucial conversations about racial discrimination, civil rights, police brutality, and the Black Lives Matter movement. Now Writer-in-Residence at Harvard Law School's Fair Justice Project and a columnist at The Intercept, King proposes real ways we can all enact social justice and equality. Location: Woodland Commons Cost: Free to students with online registration; $25 for all others. Snow date: Friday, February 9, 2018 Sponsors: Office of Diversity, Equity and Inclusion; the Frederick Douglass Unity House; and Black History 4 Seasons Council Contact: Office of Diversity, Equity and Inclusion, email@example.com or 508-999-8008
Frederick Douglass 200th Birthday Celebration
Save the date! More details to follow. Contact: Donna Moore, firstname.lastname@example.org or 508-999-9222 Sponsors: Frederick Douglass Unity House & Black History 4 Seasons Council
Presidents' Day Holiday: no classes
Presidents' Day holiday, no classes today.
Follow Monday's class schedule
Follow Monday's schedule.
Science Fiction Book Club meeting
Join the Science Fiction Book Club for our February meeting! We'll be discussing Do Androids Dream of Electric Sheep? By Philip K. Dick. All are welcome! Questions? Contact Hilary Kraus at email@example.com
Last day to file Pass/Fail
Today is the last day to file Pass/Fail.
Federal Government Panel
Federal government employer panel will discuss the hiring process for federal jobs and the job market for different fields in the government sector. Come and learn about different types of federal employers (such as Office of the Inspector General, IRS-Criminal Investigation sector and more!) Working in federal government is rewarding learn how you can support your country and love your work!
Spring recess begins (after last class or lab)
Spring recess begins today after last class or lab. NOTE: Please consult the PCE calendar if you are taking courses through Professional and Continuing Education.
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