A discussion on the surface interactions between different biological tissues and biomaterials. Protein adsorption to biomaterials, selective protein surface binding, biomolecule-nanomaterial interactions, ligand-functionalized biomaterial surfaces, growth factors on biomaterial scaffolds, cell and tissue interactions with biomaterials, functionalization of materials to promote protein and cell interactions, hydrogel nanocomposites in biology and medicine, inflammatory response to implanted nanostructured materials, collagen-coated titanium surfaces, and prevention of postsurgical adhesions are the topics to be covered. This course will also focus on the principles of the surface interaction of implants in host environment.