Lamya Karim

Lamya Karim, PhD

Assistant Professor

Bioengineering

Bone Biomechanics Lab Website

508-999-8560

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Education

2011Rensselaer Polytechnic InstitutePhD in Biomedical Engineering
Stony Brook UniversityBE in Biomedical Engineering

Teaching

  • BNG 315 Biomechanics
  • BNG 416/516 Biomedical Devices
  • BNG 425/525 Mechanobiology
  • BMB 530 Instrumentation & Lab Experience

Teaching

Programs

Teaching

Courses

A practical, hands-on lab rotation course giving students exposure to cutting-edge research methodology in a number of different areas, with a balance between biomedical engineering and biotechnology areas. A team approach is encouraged as students employ various laboratory techniques to carry out short-term projects. Students will either rotate through a number of different experimental procedures within a single investigator's laboratory or rotate through multiple faculty laboratories, learning a particular type of methodology for which the laboratory may be noted and uses frequently. The course may also provide laboratory experiences/demonstrations at sister campuses and industrial sites where faculty members have affiliations.

A practical, hands-on lab rotation course giving students exposure to cutting-edge research methodology in a number of different areas, with a balance between biomedical engineering and biotechnology areas. A team approach is encouraged as students employ various laboratory techniques to carry out short-term projects. Students will either rotate through a number of different experimental procedures within a single investigator's laboratory or rotate through multiple faculty laboratories, learning a particular type of methodology for which the laboratory may be noted and uses frequently. The course may also provide laboratory experiences/demonstrations at sister campuses and industrial sites where faculty members have affiliations.

Written presentation of an original research topic in biomedical engineering and biotechnology, which demonstrates the knowledge and capability to conduct independent research. The thesis shall be completed under the supervision of a faculty advisor. An oral examination in defense of the thesis is required.

A culminating experience in which the student synthesizes his/her course knowledge and experimental skills into a brief but detailed experimental study, which also involves cross-field interdisciplinary cooperation. Although in some cases this project may be done individually under the supervision of one faculty member, it is expected that students will join in a team-based, collaborative effort involving students from a number of different disciplines, post-doctoral fellows and industry representatives and with intercampus participation.

Investigations of a fundamental and/or applied nature. Independent Research is often work on a future dissertation undertaken before the student has satisfied the qualification steps for BMB 720. With approval of student's graduate committee, up to 15 credits of BMB 630 may be applied to the 30-credit requirement for dissertation research.

Investigations of a fundamental and/or applied nature. Independent Research is often work on a future dissertation undertaken before the student has satisfied the qualification steps for BMB 720. With approval of student's graduate committee, up to 15 credits of BMB 630 may be applied to the 30-credit requirement for dissertation research.

Investigations of a fundamental and/or applied nature representing an original contribution to the scholarly research literature of the field. PhD dissertations are often published in refereed journals or presented at major conferences. A written dissertation must be completed in accordance with the rules of the Graduate School. Admission to the course is based on successful completion of the PhD comprehensive examination and submission of a formal proposal endorsed by the student's graduate committee and submitted to the appropriate BMEMT Graduate Program Director.

Introduction to the biotransport phenomena in biomanufacturing systems and unit operations. Emphasis is placed on principles and applications of fluid and mass transport processes in bioreactors, cell, tissue and organ systems. Topics include fundamentals of diffusion and mass transport in and out of cells, immobilized catalysts and biofilms; principles and significance of chemical and biochemical reaction kinetics; and fluid and mass transport in pipes and culture vessels, as well as organs and medical and diagnostic devices.

Introduction to the mechanical behavior of biological tissues and systems. Specific topics include: structure and function of biological tissues, mechanical properties of natural and prosthetic materials, and analysis of both rigid body and deformational mechanics applied to biological tissues including bone and soft connective tissues. Basic concepts of deformable body mechanics, including stress and strain analysis, viscoelasticity, muscle action and applications to common problems in orthopedic biomechanics.

Introduction to the mechanical behavior of biological tissues and systems. Specific topics include: structure and function of biological tissues, mechanical properties of natural and prosthetic materials, and analysis of both rigid body and deformational mechanics applied to biological tissues including bone and soft connective tissues. Basic concepts of deformable body mechanics, including stress and strain analysis, viscoelasticity, muscle action and applications to common problems in orthopedic biomechanics.

Research

Research Interests

  • Biomechanics
  • Mechanobiology
  • Orthopedics
  • Skeletal Aging & Osteoporosis
  • Diabetes & Obesity

Skeletal fragility in patients with type 2 diabetes is a growing public health issue. The prevalence of diabetes is increasing rapidly, and diabetics have three times greater fracture risk compared to non-diabetics. The causes of diabetic skeletal fragility are not well established, which makes it difficult for clinicians to make decisions regarding fracture prevention in this population. Numerous micro-scale changes may contribute to skeletal health issues in these patients. For instance, changes in bone matrix composition due to accumulation of non-enzymatic chemical crosslinks can lead to poor bone quality and in turn deteriorate bone’s mechanical integrity. These crosslinks can also lead to an increase in the formation of micro-scale damage within bone. Further, some patients have altered bone microarchitecture that could contribute to their increased fracture risk, and these microarchitectural changes may result from altered bone cell behavior. Thus, we aim to investigate the biomolecular and cellular mechanisms of skeletal fragility in diabetes and other major clinical conditions. The ultimate goal of our research is to help improve diagnostic methods for fracture risk assessment and clinical management of patients at risk for fracture.

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