PhD Dissertation Proposal Defense by Yu Hsiang Cheng
Advisor: Dr. Maolin Guo, Research Advisor, Chemistry & Biochemistry Dept.
Committee members:
- Dr. Shuowei Cai, Committee Member, Chemistry & Biochemistry Dept.
- Dr. David Manke, Committee Member, Chemistry & Biochemistry Dept.
- Dr. Tracie Ferreira, Committee Member, Bioengineering Dept.
Abstract
Platinum-based drugs are widely used for cancer treatment, but their clinical effects are still limited due to problems such as systemic toxicity, low solubility, and weak tumor selectivity. The aim of this study is to develop oxaliplatin-derived Pt–DACH complexes with better cytotoxicity, improved water solubility, and more selective to cancer cells. In my preliminary work, several Pt–DACH complexes with carboxylic ligands have been synthesized. Compared with oxaliplatin, these compounds, displayed much higher solubility in water and improved cytotoxicity against Caco-2 colorectal cancer cells. Tumor-targeting molecules will be conjugated to the new Pt–DACH complexes to create targeted anticancer agents. Moreover, nanogel delivery systems will be developed to improve their tumor selectivity and release control. The novel Pt complexes and conjugates will be characterized and their tumor targeting specificity will be evaluated in model cancer cells. This work is expected to create new platinum complexes with improved potency, better water solubility, higher tumor selectivity and lower side effects for potentially better therapeutic performance.
Zoom Meeting:
Meeting ID: 993 4883 6693
Passcode: 225165
Virtual
Heather Blaser
508-999-8587
hblaser@umassd.edu
https://umassd.zoom.us/j/99348836693?pwd=HmyCZwSxrthFN5PVKhMWuC6x7Inkh8.1