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BMEBT Doctoral Proposal Defense by Kosar Fateh

Tuesday, September 29, 2026 at 1:00pm to 2:00pm

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Tracie Ferreira
tferreira@umassd.edu
https://us05web.zoom.us/j/84126380042?pwd=5bxJk3kSM3rZj1mNsaPSV2kwPbUxQm.1

Abstract

Melanoma remains a highly aggressive malignancy in which therapeutic resistance and recurrence are partly driven by cancer stem-like cells (CSCs). This research proposes a multifunctional lipid–polymer hybrid nanoparticle platform co-loading cisplatin, honokiol, and indocyanine green (ICG) to integrate chemotherapy, natural-product-based therapy, and near-infrared (NIR)-responsive photothermal treatment. Using SK-MEL-28 melanoma spheroids as a three-dimensional model enriched in stem-like characteristics, the study will investigate treatment-induced cytotoxicity, reactive oxygen species generation, and changes in CSC-associated markers, including CD133, CD271, and ABCB5. Particular emphasis will be placed on determining whether controlled ROS generation can modulate CSC fate while enhancing therapeutic response. This work aims to establish a multifunctional strategy for targeting both bulk melanoma cells and stem-like populations, with the long-term goal of overcoming therapeutic resistance and reducing tumor recurrence.

ADVISORS:  

  • Dr. Tracie Ferreira, Department of Bioengineering (tferreira@umassd.edu)
  • Dr. Kihan Park, Department of Mechanical Engineering (kpark1@umassd.edu)

COMMITTEE MEMBERS:      

  • Dr. Rachael Siriani, Department of Neurological Surgery, University of Massachusetts Chan Medical School
  • Dr. Lamya Karim, Department of Bioengineering, UMassD
  • Dr. Milana Vasudev, Department of Bioengineering, UMassD                                     

NOTE: All Bioengineering Students are ENCOURAGED to attend.