BMEBT MS proposal presentation by Sean Crowley
Biomedical Engineering & Biotechnology
BMEBT MS Thesis Proposal Presentation by Sean Crowley
Date: January 30, 2026
Time: 11 AM
Location: Zoom - https://umassd.zoom.us/j/96074639603?pwd=ho3qb8vJrG22aPkVhvb8rKb1gZeuqK.1
Title: Comparison of Ribose and Glucose for In Vitro Glycation of Human Cortical Bone In Presence of a Glycation Inhibitor
Abstract:
Patients with diabetes are at a much higher risk of experiencing bone fractures compared to non-diabetic populations. This happens despite diabetics having relatively normal or high bone mineral density, causing questions as to why this occurs. Past research has shown that diabetic bone tissue has a higher prevalence of non-enzymatic glycation, the process of sugars altering proteins in the matrix to form advanced glycation end-products. In vitro incubation simulations have been successfully used to reflect the process of non-enzymatic glycation in bone tissue. These simulations normally use ribose as the extracellular sugar source. Even though glucose is more physiologically relevant, it has little documentation in its usage in these simulations. In this project, we will investigate the effectiveness of both ribose and glucose incubations in simulating a diabetic state. We will also test the incubations with and without metformin, a known glycation inhibitor that happens to be the most commonly prescribed diabetic medication.
Advisor: Dr. Lamya Karim, Dept. of Bioengineering (lkarim@umassd.edu)
Committee Members:
- Dr. Tracie Ferreira, Dept. of Bioengineering
- Dr. Qinguo Fan, Dept. of Bioengineering
All BMEBT graduate students are encouraged to attend, and all interested parties are invited.
Online
Lamya Karim
5089998560
lkarim@umassd.edu
https://umassd.zoom.us/j/96074639603?pwd=ho3qb8vJrG22aPkVhvb8rKb1gZeuqK.1